The north-western hybrid cultures of the subcontinent included the Indo-Greeks, the Indo-Scythians, the Indo-Parthians, and the Indo-Sassinids. The first of these, the Indo-Greek Kingdom, founded when the Greco-Bactrian king Demetrius invaded the region in 180 BCE, extended over various parts of present-day Afghanistan and Pakistan. Lasting for almost two centuries, it was ruled by a succession of more than 30 Greek kings, who were often in conflict with each other. The Indo-Scythians were a branch of the Indo-European Sakas (Scythians), who migrated from southern Siberia first into Bactria, subsequently into Sogdiana, Kashmir, Arachosia, Gandhara and finally into India; their kingdom lasted from the middle of the 2nd century BCE to the 1st century BCE. Yet another kingdom, the Indo-Parthians (also known as Pahlavas) came to control most of present-day Afghanistan and northern Pakistan, after fighting many local rulers such as the Kushan ruler Kujula Kadphises, in the Gandhara region. The Sassanid empire of Persia, who were contemporaries of the Guptas, expanded into the region of present-day Pakistan, where the mingling of Indian and Persian cultures gave birth to the Indo-Sassanid culture.
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